An artificial pancreas system that closely mimics the body’s blood sugar control mechanism was able to maintain near-normal glucose levels without causing hypoglycemia in a small group of patients.The system, combining a blood glucose monitor and insulin pump technology with software that directs administration of insulin and the blood-sugar-raising hormone glucagon, was developed at Boston University (BU).The first clinical trial of the system was conducted by Harvard researchers at Massachusetts General Hospital (MGH) and confirmed the feasibility of an approach utilizing doses of both hormones. In their report, appearing in Science Translational Medicine, the researchers also found unexpectedly large differences in insulin absorption rates between study participants, differences they were able to account for by adjustments to the system.“This is the first study to test an artificial pancreas using both insulin and glucagon in people with type 1 diabetes. It showed that, by delivering both hormones in response to frequent blood sugar tests, it is possible to control blood sugar levels without hypoglycemia, even after high-carbohydrate meals,” says Steven Russell, a Harvard Medical School (HMS) instructor in medicine in the MGH Diabetes Unit, who co-led the research team with Edward Damiano of the BU Department of Biomedical Engineering.In type 1 diabetes, the insulin-producing beta cells of the pancreas are destroyed by the immune system, requiring insulin treatment to regulate blood sugar levels. Intensive glucose control involving frequent blood sugar testing and insulin administration can delay or prevent long-term complications – such as retinal damage, kidney failure, or cardiovascular disease – but is extremely demanding and difficult to maintain. Continuous glucose monitors and insulin pumps can help, but patients remain at risk for hypoglycemia, a potentially life-threatening drop in blood sugar caused by too much insulin.Because any administration of insulin, even by an artificial pancreas system, has been associated with the risk of hypoglycemia, BU investigators Damiano and lead author Firas El-Khatib developed a system that both accounts for the rate of insulin absorption and also incorporates glucagon, a hormone naturally released by the pancreas to raise blood sugar levels. While the alpha cells of the pancreas that produce glucagon are not destroyed in people with type 1 diabetes, the cells no longer release glucagon in response to low blood sugar.“Large doses of glucagon are used as a rescue drug for people with severely low blood sugar,” explains Damiano. “Our system is designed to counteract moderate drops in blood sugar with minute doses of glucagon spread out throughout the day, just as the body does in people without diabetes.” In 2007 Damiano’s team tested the system in diabetic pigs, which led to FDA approval of the human trial.The current study enrolled 11 adults with type 1 diabetes and was primarily designed to test the software that controls the system. To get the most accurate glucose levels, the system used a monitor that directly reads blood sugar through a sensor placed into a vein instead of a continuous glucose monitor that takes readings under the skin.Participants’ blood sugar was controlled by the system for 27 hours, during which time they ate three standardized, high-carbohydrate meals and slept through the night at the hospital. While the system kept glucose levels close to the target range for six participants, five others experienced hypoglycemia significant enough that they needed a dose of orange juice to raise their blood sugar.Close analysis of participants’ blood-insulin levels revealed a nearly fourfold difference in the rate at which individuals absorbed and cleared the fast-acting insulin used in the study, with some rates of absorption being much slower than anticipated. Since the controlling software determined dosage based on the expected rate of insulin absorption, participants who absorbed at a slower rate received excessive doses, leading to hypoglycemia.A test of participants’ response to a single insulin injection verified that some had consistently slow and some consistently fast rates of insulin absorption. Rates of absorption also varied too much from experiment to experiment, even on an individual basis, to allow participant-specific dosage calculations.After globally adjusting the software parameters to a slower insulin absorption rate, the researchers conducted repeat experiments in the same participants. This time none of the slow-absorption participants experienced hypoglycemia significant enough to require intervention. Blood-sugar levels were only slightly higher in repeat experiments involving participants with fast insulin absorption, showing that the adjusted software parameters were effective for all study participants and may be adequate for everyone with type 1 diabetes.The elimination of episodes of hypoglycemia in repeat experiments involving the same participants affirmed that the initial mismatch between parameter settings and insulin absorption rate had been the cause of the hypoglycemia. All previous reported studies of artificial pancreas systems have included episodes of hypoglycemia, but this is the first study to confirm and address the cause of that hypoglycemia.Later this spring the researchers will begin a follow-up study with a system using the revised settings and driven by an FDA-approved continuous glucose monitor. Those experiments will last more than 48 hours and include children as well as adults. The investigators also plan to compare the insulin/glucagon system with a version that uses only insulin. “The device we ultimately envision will be wearable and incorporate a glucose sensor inserted under the skin that communicates wirelessly with a pump about the size of a cell phone,” says Harvard’s Russel. “The pump would administer insulin and probably glucagon, and would contain a microchip that runs the control software.”Damiano, whose 11-year-old son was diagnosed with type 1 diabetes at the age of 1, adds, “a system like this would replace the need for people to constantly check their blood sugar and to make treatment decisions every few hours. It would need to be maintained but could take over the decision-making process, closely emulating a functioning pancreas. It wouldn’t be a cure, but it has the potential to be the ultimate evolution of insulin therapy for type 1 diabetes.” Damiano is an associate professor of Biomedical Engineering at Boston University.The study was supported by grants from the Juvenile Diabetes Research Foundation, the Wallace H. Coulter Foundation, the Charlton Fund for Innovative Research in Diabetes and the National Center for Research Resources. Co-authors of the paper are David M. Nathan, MD, professor of medicine at HMS and director of the MGH Diabetes Center, and Robert Sutherlin, RN, also of the MGH Diabetes Center.
By Julieta Pelcastre/Diálogo January 07, 2020 The Nicaraguan government strengthens its pattern of repression.On November 13, Juan Carlos Ortega Murillo, son of Nicaraguan President Daniel Ortega and Vice President Rosario Murillo, announced the creation of the May 4th Sandinista Movement (Movimiento Sandinista 4 de mayo). Ortega Murrillo made the announcement in front of the Private Enterprise Superior Council (COSEP, in Spanish), and said that Nicaraguan businessmen were enemies of the people for opposing the regime’s ideals. On May 4, 1927, Augusto Sandino, who inspired the Sandinista movement, refused to sign the Espino Negro Pact, which sought to put an end to a civil war between the conservative government and nationalist opposition groups.“In early November, the president accused businesses of distorting economic figures in order to spread fear,” Eliseo Núñez, an expert in public policy and legislative law, told Diálogo from Managua. “Consequently, Ortega might exert pressure on them with taxes and company expropriations, as he did with the media.”In response, COSEP reported that the government and its partisan structures are conducting a media campaign and public actions against organizations and private sector leaders, with threats that promote a “culture of intolerance, hatred, and death.” Political instability has affected the conditions with which to do business and triggers company shutdowns and unemployment, it added.“Economic revival and a democratic state won’t be possible until the civil rights and political liberties of all Nicaraguans are restored,” Francys Valdivia Machado, president of the Mothers of April Association, told Diálogo. Valdivia Machado escaped to Mexico after receiving threats from the Sandinista regime, and continues her work in exile. Her brother, Franco Valdivia, was murdered during the protests of April 2018.“The movement led by Ortega’s son represents violence, persecution, and repression, and it reflects the Sandinista front’s fear of losing power,” Valdivia Machado added. “The presidential couple is willing to do anything to win the presidential election [in 2021].”In addition to leading the new Sandinista movement, Ortega Murillo is the director of TV Channel 8, and owns Difuso Comunicaciones, one of the companies responsible for creating pro-government propaganda, said the Spanish daily La Vanguardia.“The Ortega Murillos are playing with the human rights of Nicaraguans. We don’t want war, but a peaceful and solid solution to the crisis that the country is going through,” Valdivia Machado concluded.
Categories: Letters to the Editor, OpinionThe lines were 100, and in the larger cities 1,000. They had finally done it. It took decades before the majority decided to be the majority. It took the lives of thousands more children for the majority to learn that they, in fact, had had the power all along.Then all hell broke loose. The “lobby” pulled their fear out of their closets and drawers and cabinets, and went out on the streets. There were banners calling for civil war. There were bombings and more would die defending that “amendment.”As time moved on, the truth of the many extinguished the fear of the few. Glints of hard metal were visible in the sunlight. They put their fears on the conveyor belt and turned to sign some official papers. When it was over, they went back to their homes.Naturally, the murders subsided, but the afflicted turned to other ways to soothe their pain. It was all right, though. Love and truth prevailed and therapy replaced bullets.Michael Daugherty Sr.Clifton ParkMore from The Daily Gazette:High-risk COVID exposure reported in Clifton ParkFoss: Should main downtown branch of the Schenectady County Public Library reopen?EDITORIAL: Beware of voter intimidationControversial solar project goes before Clifton Park Planning BoardGame 7: Shenendehowa grad and Braves rookie Ian Anderson gets start with World Series spot on the li…
Hon Hai Precision Industry, Apple’s main production partner, cut its 2020 revenue growth outlook after assessing the potential impact of a deadly coronavirus outbreak.Hon Hai, which makes the vast majority of the world’s iPhones from the central Chinese city of Zhengzhou, is now projecting a sales increase of 1 percent to 3 percent this year, Chairman Young Liu told Bloomberg News in a text message. That’s down from a Jan. 22 forecast of 3 percent to 5 percent, before the epidemic spread around the globe, and lags the 5.4 percent average of analysts’ projections.The contagion is expected to disrupt Apple’s carefully calibrated production chain centered on China, while also dampening consumer demand and overall economic growth. Hon Hai, an important manufacturer also for major brands from HP to Sony, said Tuesday it still expects to be able to restart facilities throughout China on schedule, according to a text message sent to Bloomberg News. Suppliers such as Quanta Computer, Inventec and LG Display also said they would go back to work next week in China. But while Chinese officials and companies have targeted Feb. 10 as the date to resume work in much of the country, doubts about the timing have grown in recent days as the virus death toll rises, workers find themselves stuck in municipal lockdowns and the transport of people and goods has been hampered.”Given current market conditions, we are lowering to 1 percent -3 percent,” Liu replied when asked about whether Hon Hai will cut its original sales growth forecast for this year.Hon Hai’s shares stood largely unchanged Wednesday after having slid about 11 percent since a broader Asian market selloff began in mid-January.Topics :
Hong Kong based billionaire Tony Fung was not expected to be impacted by the new rules. Picture: Marc McCormackMore from newsMould, age, not enough to stop 17 bidders fighting for this home2 hours agoBuyers ‘crazy’ not to take govt freebies, says 28-yr-old investor2 hours agoOfficially the real estate restriction was on deals worth more than $US1billion, but The Courier-Mail was told a wider net had already been cast, with Chinese nationals transferring cash here having to sign statements declaring the funds were not for real estate.Agents have reported a flurry of Chinese investors wanted to offload new developments at discounted rates — a boon for locals via reduced prices and less competition. Cash-strapped Chinese buyers who paid 10 per cent deposits on units were willing to back out of deals with as little as a third of their deposit in hand “because 3 per cent (of the 10) is better than nothing”.Brisbane was expected to bear the brunt of any Queensland fallout, especially in new developments. Realestate.com.au data showed the top 10 Queensland suburbs that attracted Chinese attention this year were Carindale, St Lucia, Indooroopilly, Hope Island, Calamvale, Sunnybank, Southport, Sunnybank Hills, Cairns and Eight Mile Plains. The Chinese Cabinet has begun a sting on offshore real estate deals and overseas casino funding. Picture: Stewart McLeanBRISBANE real estate deals are collapsing after a new Chinese Government sting on offshore investment.Millions sunk into real estate are at risk, according to experts, but Queensland may have avoided a multibillion-dollar hit from a related Chinese Government ban on casino investments.Property experts believe the situation has created a perfect storm for locals with deals aplenty as Chinese buyers topple on funding. Brisbane was expected to bear the brunt of any Queensland fallout, mostly because of unit deals. Picture: AAP Image/Marc RobertsonThis after China’s State Council documented restrictions on investments in real estate and banned any funding of new casinos over concerns that private firms were carrying too much debt.The $3 billion Queens Wharf casino – whose joint venture partner Chow Tai Fook Enterprises owns China’s biggest jewellery firm – and billionaire Tony Fung’s millions sunk into hotel and casino plans along the Queensland East Coast would both have been in the crosshairs, but their Hong Kong bases appear to have shielded them for now.A spokesman for Mr Fung – who’s in Hong Kong this week – said “to the best of our understanding the new regulations do not apply to Hong Kong, where Tony resides, so will not have any impact on Aquis’ Australian strategy”. Tourists Weihua Chen (23) and Dongwan Wang (22) on Surfers Paradise beach. Busloads of Chinese nationals previously flocked to Queensland on holiday/property trips. Picture by Scott FletcherJust last year, busloads of Chinese buyers were driven around Brisbane to look at potential investments but demand had dropped so sharply those trips have had to be culled, said Harcourts agent Conrad Leisemann.Yong Real Estate agent Tom Zhang, who deals with many Chinese buyers and sellers in Sunnybank, said the moves were a “double threat” for Chinese investors.“Firstly they made it hard to borrow money, so many people said ‘okay we will use cash’, and now the cash has been restricted,” he said. “The Sunnybank outer market has been greatly affected by those changes. It’s good timing for local buyers to buy before the rules are loosened again.” Place Projects director Lachlan Walker said the lending crackdown was heavily felt from late last year, but the new restrictions would pummel Sydney and Melbourne more than Brisbane.“Chinese buyers’ preference has always been Sydney and Melbourne, so it will impact those markets more than Queensland,” he said. “But Chinese investment in residential product gave us our volume. They did underwrite a lot of developments that occurred here and we can’t depend on them now.”REIQ CEO Antonia Mercorella said Queensland had to find an alternative to fill the gap left by Chinese investors.“Queensland needs investors in both residential and commercial property, so our strong hope is that if one investor group starts to contract another will be able to increase to fill the gap.“Queensland is a desirable investment destination and hopefully our strong value proposition will continue to attract local and international investors to our shores.”
The new relationship will see a greater focus on collaboration in areas of governance, transparency and financial stability, all areas where HFSB chair Amelia Fawcett said both groups were “very much aligned”.The partnership would also see the HFSB work more closely with sovereign funds when drafting its industry standards.Fawcett said: “The HFSB relies on hedge fund managers and investors to work together to set industry standards, and we welcome closer dialogue with sovereign wealth funds, which are a large and influential hedge fund investor group.”HFSB trustee David George, head of debt and alternatives at Australia’s AUD118bn (€78.7bn) Future Fund, said the Australian investor was working to reshape the investment environment to “prioritise the interests of the asset owners”.He added: “The Future Fund supports the HFSB and the IFSWF, which provide platforms to foster constructive dialogue within the SWF community and between hedge fund managers and asset owners, and we look forward to helping shape the joint initiatives between the HFSB and the IFSWF.” Sovereign wealth funds (SWFs) worth $5.5trn (€4.8trn) have joined the Hedge Fund Standards Board (HFSB), allowing for greater influence on the disclosure framework of the funds.The International Forum of Sovereign Wealth Funds (IFSWF), covering more than 30 of the world’s sovereign investors, has agreed to be an observer to the HFSB.Adrian Orr, chief executive at the NZD28bn (€16.9bn) New Zealand Super Fund and IFSWF chair, said he was “delighted” to forge a closer relationship with the HFSB to share the knowledge and experience amassed by the sovereign funds.“This relationship will help ensure sovereign wealth funds have a voice in the hedge fund standard-setting process,” he said.
By Mark GleesonCAPE TOWN (Reuters) – The decision on Caster Semenya’s challenge to continue competing without any restrictions will be announced by the Court of Arbitration for Sport (CAS) at 1000 GMT tomorrow.The double Olympic 800m champion is challenging the sport’s governing body, International Association of Athletics Federations (IAAF), over its decision to restrict testosterone levels in female runners.The IAAF wants the South African and other female athletes with differences of sexual development (DSD) to take testosterone blockers.Under the new rules, which will apply to women events between 400 metres to the mile, athletes classed as having DSDs must reduce their blood testosterone level to below five (5) nmol/L for a period of six months before they can compete. They must then maintain it below that level continuously. Semenya, 28, has been waiting since February following her appeal against an IAAF regulation, which said female athletes classed as having DSDs gain an unfair advantage due to their higher testosterone levels.Testosterone is a hormone that increases muscle mass, strength and haemoglobin – which affects endurance. CAS had been due to announce its decision in March but postponed it several times. Semenya’s dominance of the middle distances has been labelled unfair by many of her competitors but the proposed restrictions have also been branded as discriminatory.Several expert witness were called by both sides during a five-day hearing presided by three judges at CAS’s headquarters in Lausanne, Switzerland in February. Semenya won 1,500m and 5,000m golds at the South African Athletics Championships over the past few days. Should her appeal be unsuccessful, Semenya would have to meet the IAAF requirements to keep running in the 800 and 1500 metres, but they would not apply were she to step up to 5,000.Last month, Semenya said in a statement released through her lawyers that she wanted to differentiate her case from those of transgender athletes who were born male. “Ms Semenya is a woman. There is no debate or question about this and the IAAF does not dispute this,” the statement said.“She was born a woman, raised a woman, socialised as a woman and has competed as a woman her entire life. “Ms Semenya does not wish to undergo medical intervention to change who she is and how she was born. She wants to compete naturally.”The IAAF has previously said it is confident of the legal, scientific and ethical basis for the regulations and expects CAS to reject Semenya’s appeal.
Heartland defender, Brownbraye Okpus will not be available for his side’s today’s top flight clash at Shooting Stars Sports Club (3SC) at the Lekan Salami Stadium in Ibadan.Okpus picked an injury in his side NPFL matchday 11 clash 2-1 win against Rivers United on Sunday at the Dan Anyiam Stadium in Owerri. An official of the Owerri outfit, Solomon Onuh said the medics advised that the player be rested for the clash at the Oluyole Warriors to avoid worsening the shoulder injury.“Okpus is not on the trip to Ibadan for today’s NPFL Week 12 clash against Shooting Stars Sports Club (3SC).“The doctors that treated him from the injury he picked in Sunday’s duel against Rivers United advised further rest to help the shoulder injury heal completely.“Okpus will just miss the clash at 3SC but will be available for selection against Sunshine Stars in Owerri.“Of course, the coaches know what to do in the absence of the rugged defender to ensure we get good result at 3SC.“Okpus’ absence will be felt in the game but will not affect the fortune of the side as there will always be replacements.“It will offer his replacements wonderful opportunity to raise their games as well as chance laying a permanent claim for the position.“Both teams have tradition and respect for each other it is certain to be an interesting game that the players will always want to go home with something positive,” said Onuh tosupersport.com
Share Share HKJC closes OCBBs amid rising public health concerns July 13, 2020 Submit Related Articles StumbleUpon MansionBet adds Bristol City to sponsorship portfolio August 20, 2020 W88 secures Crystal Palace front-of-shirt sponsorship August 3, 2020 South London Premier League football club Crystal Palace FC, continues to expand its commercial presence within Asian markets announcing its first ever ‘shirt sleeve’ sponsorship with Chinese football app Dongqiudi.Starting this 2017/18 EPL season, the Dongqiudi logo will appear on the ‘Eagles’ home and away football jerseys, featuring on the left sleeve.Crystal Palace management announced the new sponsorship, as the football club tours Asia in which it will play the ‘Premier League Asia Trophy’ at the Hong Kong Stadium.Launched in 2013, Dongqiudi is a popular Chinese football app, which brings extensive information of international football matches and competitions. The app further engages its audience by creating social clubs for Chinese f fans to discuss and debate all things football.To date, Dongqiudi details that it has had +30 million downloads, with the app reporting more 3 million unique daily users.Commenting on the partnership Steve Parish Chairman of Crystal Palace stated “We are delighted to have Dongqiudi as the club’s first shirt sleeve partner. Dongqiudi’s platform gives us a fantastic opportunity to promote Crystal Palace in China whilst giving their brand exposure to the club’s growing international following and the wider global Premier League audience.”Last June Crystal Palace announced its ‘biggest shirt sponsorship to date’ welcoming Asian facing bookmaker ManBetX as EPL 2017/18 ‘Official Club Sponsor’
Neville Burdock – Sporting IndexTwenty years on from one of their biggest ever losses, Sporting Index has returned with the infamous ‘World Cup wides market’, which saw the spread betting firm lose over half a million pounds in the 1999 Cricket World Cup.The World Cup wides market, pioneered by Sporting Index, was introduced for the first time in 1999 and has been available to punters in every Cricket World Cup tournament since, but traders (as well as bowlers) underestimated how much this would swing in English conditions.That year’s tournament saw the introduction of the white ball in the Cricket World Cup for the first time, and Sporting Index initially predicted there would be 255 wides in the 42-game tournament, which was quickly pounced on by the betting community.After the dust settled on the 979th and final wide of the tournament, Sporting Index traders were left licking their wounds, with the company facing huge losses of £500,000.This year, the trading team returns to the site of its greatest loss, and after 20 years’ experience in the white-ball game, have priced this year’s wides at 715.Prior to the white ball introduction, World Cup teams averaged 8.15 wides each per game, compared to 16.7 per team with the white ball. There was also an average of 817 wides per tournament with the white ball, compared to 300 per game before its adoption.The largest number of wides bowled in a single World-Cup game came in India’s win over Kenya in 1999, with the two sides bowling 52 wides between them.As for the tournament itself, Sporting Index is predicting that there will be 535 total sixes during the tournament and that Eoin Morgan’s England side will contribute 80 of these. The spread betting firm are also estimating that 45 batsmen will score centuries during the 48 matches.Neville Burdock, Head of Trading at Sporting Index, said: “The 1999 Cricket World Cup wides market was an absolute disaster for us, and a real celebration for punters. This year, we are willing to take on the wides market again but will be pricing the total at 715 across the tournament. “With tactical, disciplined bowling more prevalent than ever, we expect significantly less wides than the 979 that stung us 20 years ago, but with a new ball at each end, maybe a few more than the original 255 that was first predicted with the red ball.” Related Articles UK not leaving EU on October 31 trading on exchanges at 97% October 25, 2019 StumbleUpon Share Frankie Dettori rides with Sporting Index May 29, 2020 Submit Paytm targets number 1 fantasy sports status in India June 18, 2019 Share